NEUROLOGIC AND NEUROPATHOLOGIC OBSERVATIONS IN LUPUS ERYTHEMATOSUS*Because of the protean neurologic manifestations and ill defined neuropathology of systemic lupus erythematosus, a study was made of patients followed at the Massachusetts General Hospital with this clinical and pathological diagnosis. Between 1945 and 1961 brains were obtained at autopsy from 24 of these patients; their clinical and general pathological abnormalities conformed to the usual findings in this disease. Neurologic or psychiatric manifestations, or both, were observed in 18 (75 per cent); these included seizures (12), cranial-nerve abnormalities (10), hemiparesis (4), paraplegia (1), peripheral neuropathy (1), paresthesias (2), autonomic abnormalities (1) and . . .